Friday 20 August 2010

Holford's In Vitro Inconsistency

It has been pointed out that Patrick Holford has recently noted the limitations of in vitro studies in the context of a study that found high doses of antioxidants could potentiate DNA damage:

“We don’t have the full study available yet and I think it’s significant that it is a cell study, rather than one carried out on humans,” he says. “We have to know that it’s a cell study and may have some limitations. The devil is in the detail.“

An example is given of Holford's approach to studies conducted in the lab that accord with his beliefs:
In his Optimum Nutrition Bible, Patrick Holford made this statement: “AZT, the first prescribable anti-HIV drug, is potentially harmful, and proving less effective than Vitamin C.” This statement was ‘supported’ by a reference to a paper that described an experiment in HIV-infected T-lymphocytic cell lines. This has been covered by Ben Goldacre here (with follow-up here and here).
Here are some further examples: on the Holford Watch blog.

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